Speaker
Description
Cellular tissue simulations can be computationally demanding, which restricts them to simplified cell geometries and low spatial resolution. Here I present two recently introduced cell-based simulation programs written in C++, PolyHoop and SimuCell3D, which are designed to efficiently model cellular tissues with detailed subcellular resolution. PolyHoop simulates cellular monolayers in 2D using flexible hoops to represent individual cell membranes, while SimuCell3D models cell membranes, nuclei, and extracellular matrices in 3D using triangulated surfaces and an automatic cell polarization algorithm. Both tools are highly efficient, enabling simulations with many thousand deformable cells. They are open source, freely available, and easy to use. In this talk, I will give a short live demo that shows the tools in action in a typical scenario featuring a proliferating tissue.
