Speaker
Description
The buildup of toxic reactive oxygen species (ROS) is a significant contributor to retinal degeneration and cellular dysfunction. It has been shown that the glutathione (GSH) antioxidant system and nicotinamide adenine dinucleotide phosphate (NADPH) play an important role in the detoxification of ROS. Existing models describe these dynamics with system of ordinary differential-algebraic equations. However, ROS diffuses across retinal cells, which is not addressed in existing models. Understanding the spatial behavior of ROS could inform treatment strategies, but doing so requires the use of more advanced numerical tools. In this presentation, we address challenges and strategies for domain meshing, temporal discretization, and computational expense.
