Speaker
Description
Multi-scale mathematical models of viral infections obviously require two main models: a population-scale model of transmission between hosts, and an individual-scale model of the course of infection. However, attempting to integrate these into a coherent multi-scale model leads us to confront their coupling at the moment of transmission, and during the first moments of the infection process. These parts of the overall process are generally poorly understood in comparison with the large-scale epidemic dynamics (population scale) and the large-scale viral dynamics (individual scale). In this talk, I will describe this problem, and then briefly summarize several projects where we closely examined transmission and early-time dynamics for viral infections, including human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) and murine cytomegalovirus (MCMV). This talk represents joint work with many trainees and colleagues over the last twenty years and effusive acknowledgments will be given.
