Speaker
Laurence Calzone
(Institute Curie)
Description
Understanding cancer invasion requires linking intracellular regulatory processes with multicellular dynamics. Boolean modelling provides a powerful framework to describe phenotypic transitions such as the mesenchymal–epithelial transition (MET), capturing how signalling networks and environmental cues regulate cell plasticity and state switching.
At a larger scale, intracellular logical models can be integrated with spatial, cell-based simulations to study tumour invasion. By coupling regulatory states with cell–matrix interactions, these models reproduce diverse invasion patterns and offer insight into how individual decision-making processes give rise to emergent collective behaviours.
Author
Laurence Calzone
(Institute Curie)
