Speaker
John Tyson
(VirginiaTech, VA, USA)
Description
In 1993, Novak & Tyson published a comprehensive model of M-phase control in frog egg extracts (J. Cell Sci. 106, 1153-1168). The model, soundly based on known molecular mechanisms, provided a unified understanding of cell-cycle transitions, mitotic oscillations, checkpoints, and wave propagation in frog eggs, yeast cells and fruit fly embryos. It made many non-intuitive predictions that were later confirmed experimentally. Later work by Novak, Tyson and their students and collaborators led to a general 'dynamical perspective for molecular cell biology,' based on detailed numerical simulations and generic bifurcation diagrams. In this talk, I will give a brief survey of how the theory developed over the intervening 30+ years.
