Speaker
Description
Mental disorders are a major contributor to the global burden of disease and often manifest as overlapping symptom profiles rather than isolated diagnoses. In clinical and digital health settings, this requires simultaneous assessment of multiple psychiatric domains, including depression, anxiety, trauma-related symptoms, substance use, and suicidality. However, current screening frameworks rely on separate disorder-specific questionnaires, producing lengthy assessments that increase response burden and limit scalability for large-scale or longitudinal monitoring. From a systems perspective, this raises the question of whether multi-disorder psychiatric risk signals are distributed across many questionnaire items or concentrated within a smaller set of core symptom dimensions. Here, we investigate structural compression in multi-disorder psychiatric assessment by identifying representative symptoms across six commonly used instruments. Our framework compresses 57 questionnaire items into a six-item representation while preserving strong predictive performance across all disorders (AUROC $\approx$ 0.90–0.97). Network analysis further shows that the selected symptoms occupy central positions within the symptom interaction network, suggesting that multi-condition psychiatric risk can be captured through a compact set of symptom dimensions.
Bibliography
@article{grotzinger_mapping_2026,
title = {Mapping the genetic landscape across 14 psychiatric disorders},
volume = {649},
issn = {0028-0836, 1476-4687},
url = {https://www.nature.com/articles/s41586-025-09820-3},
doi = {10.1038/s41586-025-09820-3},
language = {en},
number = {8096},
urldate = {2026-05-11},
journal = {Nature},
author = {Grotzinger, Andrew D. and Werme, Josefin and Peyrot, Wouter J. and Frei, Oleksandr and De Leeuw, Christiaan and Bicks, Lucy K. and Guo, Qiuyu and Margolis, Michael P. and Coombes, Brandon J. and Batzler, Anthony and Pazdernik, Vanessa and Biernacka, Joanna M. and Andreassen, Ole A. and Anttila, Verneri and Børglum, Anders D. and Breen, Gerome and Cai, Na and Demontis, Ditte and Edenberg, Howard J. and Faraone, Stephen V. and Franke, Barbara and Gandal, Michael J. and Gelernter, Joel and Hatoum, Alexander S. and Hettema, John M. and Johnson, Emma C. and Jonas, Katherine G. and Knowles, James A. and Koenen, Karestan C. and Maihofer, Adam X. and Mallard, Travis T. and Mattheisen, Manuel and Mitchell, Karen S. and Neale, Benjamin M. and Nievergelt, Caroline M. and Nurnberger, John I. and O’Connell, Kevin S. and Peterson, Roseann E. and Robinson, Elise B. and Sanchez-Roige, Sandra S. and Santangelo, Susan L. and Scharf, Jeremiah M. and Stefansson, Hreinn and Stefansson, Kari and Stein, Murray B. and Strom, Nora I. and Thornton, Laura M. and Tucker-Drob, Elliot M. and Verhulst, Brad and Waldman, Irwin D. and Walters, G. 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M. and Bass, Nicholas and Batzler, Anthony J. and Baune, Bernhard T. and Beins, Eva C. and Bigdeli, Tim B. and Cichon, Sven and Coleman, Jonathan Ri and Cuellar-Barboza, Alfredo B. and Dannlowski, Udo and David, Friederike S. and Frank, Josef and Fullerton, Janice M. and Goes, Fernando S. and Grigoroiu-Serbanescu, Maria and Hoffmann, Per and Kalman, Janos L. and Krebs, Kristi and Landén, Mikael and Lewis, Cathryn M. and Li, Qingqin S. and Lind, Penelope A. and Luykx, Jurjen J. and Manchia, Mirko and Mattingsdal, Morten and McIntosh, Andrew M. and McQuillin, Andrew and Meloni, Anna and Milani, Lili and Mitchell, Philip B. and Morris, Derek W. and Mullins, Niamh and Myung, Woojae and Nurnberger, John I. and Ophoff, Roel A. and Owen, Michael J. and Patrinos, George P. and Pisanu, Claudia and Prisciandaro, James J. and Reininghaus, Eva Z. and Rice, John P. and Rietschel, Marcella and Schulte, Eva C. and Serretti, Alessandro and Sirignano, Lea and Squassina, Alessio and Streit, Fabian and Strohmaier, Jana and Van Der Veen, Tracey and Vawter, Marquis P. and Vincent, John B. and Zandi, Peter P. and Zillich, Lea and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Adan, Roger A. and Birgegård, Andreas and Bulik, Cynthia M. and Dina, Christian and Dmitrzak-Weglarz, Monika and Docampo, Elisa and Egberts, Karin M. and Fernandez-Aranda, Fernando and Giel, Katrin E. and Gorwood, Philip and Hübel, Christopher and Hudson, James I. and Jimenez-Murcia, Susana and Jordan, Jennifer and Kalsi, Gursharan K. and Kaprio, Jaakko and Karhunen, Leila and Kas, Martien J. H. and Kennedy, Martin A. and Larsen, Janne T. and Lilenfeld, Lisa R. and Monteleone, Alessio Maria and Munn-Chernoff, Melissa A. and Nacmias, Benedetta and Petersen, Liselotte V. and Pinto, Dalila and Raevuori, Anu and Ramoz, Nicolas and Ricca, Valdo and Roberts, Marion E. and Rybakowski, Filip and Schmidt, Ulrike H. and Schosser, Alexandra and Sorbi, Sandro and Strober, Michael A. and Watson, Hunna J. and Zipfel, Stephan and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium} and Adams, Mark J. and Benros, Michael E. and Bressan, Rodrigo A. and Byrne, Enda M. and Carvalho, Carolina M. and Chaumette, Boris and Colodro-Conde, Lucia and Derks, Eske M. and Dunn, Erin C. and Fabbri, Chiara and Fanelli, Giuseppe and Foo, Jerome C. and Gadelha, Ary and Gerring, Zachary F. and Grabe, Hans J. and Heath, Andrew C. and Lehto, Kelli and Levinson, Douglas F. and Lewis, Glyn and Ota, Vanessa K. and Pan, Pedro M. and Paschou, Peristera and Potash, James B. and Riley, Brien P. and Salum, Giovanni A. and Santoro, Marcos L. and Thorp, Jackson G. and Van Der Auwera, Sandra and Webb, Bradley T. and {Nicotine Dependence GenOmics (iNDiGO) Consortium} and Baker, Timothy B. and Dick, Danielle M. and Drichel, Dmitriy and Farrer, Lindsay A. and Gaddis, Nathan C. and Hancock, Dana B. and Hokanson, John E. and Hottenga, Jouke-Jan and Johnson, Eric O. and Madden, Pamela A. and Marazita, Mary L. and Marks, Jesse A. and McNeil, Daniel W. and Nothnagel, Michael and Quach, Bryan C. and Saccone, Nancy L. and Sey, Nancy Ya and Sherva, Richard and Vrieze, Scott and Waldrop, Alex and Winterer, Georg and Young, Kendra and Zellers, Stephanie and {Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium} and Barr, Cathy L. and Barta, Csaba and Bey, Katharina and Bienvenu, Oscar J. and Boberg, Julia and Bybjerg-Grauholm, Jonas and Camarena, Adrian and Camarena, Beatriz and Cath, Danielle C. and Crowley, James J. and Dietrich, Andrea and Falkai, Peter and Fernandez, Thomas V. and Geller, Daniel A. and Grados, Marco A. and Greenberg, Erica L. and Grünblatt, Edna and Hagen, Kristen and Hanna, Gregory L. and Hansen, Bjarne and Heiman, Gary A. and Hoekstra, Pieter J. and Hougaard, David M. and Kathmann, Norbert and Klawohn, Julia and Kvale, Gerd and Lanzagorta, Nuria and Le Hellard, Stephanie and Macciardi, Fabio and Maher, Brion S. and Malaty, Irene A. and Mataix-Cols, David and Mathews, Carol A. and McLaughlin, Nicole Cr and Miguel, Euripedes C. and Müller-Vahl, Kirsten R. and Nicolini, Humberto and Nurmi, Erika L. and Okun, Michael S. and Rabionet, Raquel and Ramirez, Alfredo and Rizzo, Renata and Rodriguez-Fontenla, Cristina and Sandor, Paul and De Schipper, Elles and Singer, Harvey S. and Storch, Eric A. and Veenstra-VanderWeele, Jeremy and Wagner, Michael and Walker, Christopher P. and {Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium} and Andersen, Søren B. and Bierut, Laura J. and Chen, Chia-Yen and Daskalakis, Nikolaos P. and Disner, Seth G. and Docherty, Anna R. and Feeny, Norah C. and Grasser, Lana R. and Haas, Magali and Harrington, Kelly M. and Hesselbrock, Victor M. and Ibrahim, Mohammed H. and Katrinli, Seyma and Kimbrel, Nathan A. and Maples-Keller, Jessica L. and Meyers, Jacquelyn L. and Montalvo-Ortiz, Janitza L. and Morris, Charles P. and Pietrzak, Robert H. and Polimanti, Renato and Rosenblum, Richard J. and Rothbaum, Barbara O. and Rutten, Bart Pf and Seedat, Soraya and Smith, Alicia K. and Tarter, Ralph E. and {Schizophrenia Working Group of the Psychiatric Genomics Consortium} and Ayub, Muhammad and Campion, Dominique and Cohen, David and Consoli, Angel and Di Forti, Marta and Eriksson, Johan G. and Fedorenko, Olga Yu and Freedman, Robert and Gainetdinov, Raul R. and Giannitelli, Marianna and Giegling, Ina and Glatt, Stephen J. and Godard, Stephanie and Guillin, Olivier and Hartmann, Annette M. and Ivanova, Svetlana A. and Kibitov, Alexander O. and Konte, Bettina and Laurent-Levinson, Claudine and Levchenko, Anastasia and Murray, Robin and Nordentoft, Merete and Noto, Cristiano and Quattrone, Diego and Rujescu, Dan and Saker-Delye, Safaa and Schwab, SIbylle G. and Thibaut, Florence and Walters, James Tr and Werge, Thomas and Wildenauer, Dieter B. and {Substance Use Disorders Working Group of the Psychiatric Genomics Consortium} and Agrawal, Arpana and Baranger, David Aa and Boardman, Jason D. and Boden, Joseph M. and Bogdan, Ryan and
Bucholz, Karhleen K. and Choi, Doo-Sup and Mc Colbert, Sarah and Deak, Joseph D. and Diazgranados, Nancy and Edwards, Alexis C. and Goate, Alison M. and Goldman, David and Hack, Laura M. and Harris, Kathleen Mullan and Hartz, Sarah M. and Hayward, Caroline and Hewitt, John K. and Hopfer, Christian J. and Karpyak, Victor M. and Krauter, Kenneth S. and Krupitsky, Evgeny M. and Kuperman, Samuel and Lahti, Jari and Lahti-Pulkkinen, Marius and Lai, Dongbing and Miller, Alex P. and Palmer, Abraham A. and Palmer, Rohn H. and Pearson, John F. and Porjesz, Bernice and Preuss, Ulrich W. and Rosenblum, Daniel M. and Scherbaum, Norbert and Vanyukov, Michael and Wall, Tamara L. and Wedow, Robbee and Weiss, Stanley H. and Wetherill, Leah and Wodarz, Norbert and Zhang, Haitao and Zhao, Hongyu and Zhou, Hang and Zill, Peter and Lee, Phil H. and Kendler, Kenneth S. and Smoller, Jordan W.},
month = jan,
year = {2026},
pages = {406--415},
}
@article{kotov_hierarchical_2017,
title = {The {Hierarchical} {Taxonomy} of {Psychopathology} ({HiTOP}): {A} dimensional alternative to traditional nosologies.},
volume = {126},
issn = {1939-1846, 0021-843X},
shorttitle = {The {Hierarchical} {Taxonomy} of {Psychopathology} ({HiTOP})},
url = {https://doi.apa.org/doi/10.1037/abn0000258},
doi = {10.1037/abn0000258},
language = {en},
number = {4},
urldate = {2026-05-11},
journal = {Journal of Abnormal Psychology},
author = {Kotov, Roman and Krueger, Robert F. and Watson, David and Achenbach, Thomas M. and Althoff, Robert R. and Bagby, R. Michael and Brown, Timothy A. and Carpenter, William T. and Caspi, Avshalom and Clark, Lee Anna and Eaton, Nicholas R. and Forbes, Miriam K. and Forbush, Kelsie T. and Goldberg, David and Hasin, Deborah and Hyman, Steven E. and Ivanova, Masha Y. and Lynam, Donald R. and Markon, Kristian and Miller, Joshua D. and Moffitt, Terrie E. and Morey, Leslie C. and Mullins-Sweatt, Stephanie N. and Ormel, Johan and Patrick, Christopher J. and Regier, Darrel A. and Rescorla, Leslie and Ruggero, Camilo J. and Samuel, Douglas B. and Sellbom, Martin and Simms, Leonard J. and Skodol, Andrew E. and Slade, Tim and South, Susan C. and Tackett, Jennifer L. and Waldman, Irwin D. and Waszczuk, Monika A. and Widiger, Thomas A. and Wright, Aidan G. C. and Zimmerman, Mark},
month = may,
year = {2017},
pages = {454--477},
}
