Speaker
Description
The zebrafish serves as a powerful model of lifelong neurogenesis in vertebrates. Their Neural Stem Cells (NSCs) persist in specialized niches to generate neurons and glial cells, exhibiting high constitutive neurogenic activity and remarkable regenerative capacity \cite{Labusch2020, Grandel2006}.
Key gaps remain in understanding the molecular and cellular regulators of NSCs quiescence, activation, proliferation dynamics, migration, and fate decisions, particularly in domains like the telencephalon. Filling these gaps could inform strategies for enhancing regeneration in less neurogenic species, such as mice or humans, with implications for regenerative medicine and neurodegenerative disease therapies
\cite{Elkin2025, Kalamakis2019}.
In this poster, I will present a new mechanistic modeling framework, based on experimental data, that capture the spatio-temporal regulation of NSCs located in the adult zebrafish pallium.
Bibliography
@article{Kalamakis2019,
title = {Quiescence {Modulates} {Stem} {Cell} {Maintenance} and {Regenerative} {Capacity} in the {Aging} {Brain}},
volume = {176},
issn = {00928674},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0092867419301035},
doi = {10.1016/j.cell.2019.01.040},
language = {en},
number = {6},
urldate = {2026-03-11},
journal = {Cell},
author = {Kalamakis, Georgios and Brüne, Daniel and Ravichandran, Srikanth and Bolz, Jan and Fan, Wenqiang and Ziebell, Frederik and Stiehl, Thomas and Catalá-Martinez, Francisco and Kupke, Janina and Zhao, Sheng and Llorens-Bobadilla, Enric and Bauer, Katharina and Limpert, Stefanie and Berger, Birgit and Christen, Urs and Schmezer, Peter and Mallm, Jan Philipp and Berninger, Benedikt and Anders, Simon and Del Sol, Antonio and Marciniak-Czochra, Anna and Martin-Villalba, Ana},
month = mar,
year = {2019},
pages = {1407--1419.e14},
}
@article{Elkin2025,
title = {The {Critical} {Balance} {Between} {Quiescence} and {Reactivation} of {Neural} {Stem} {Cells}},
volume = {15},
issn = {2218-273X},
url = {https://www.mdpi.com/2218-273X/15/5/672},
doi = {10.3390/biom15050672},
abstract = {Neural stem cells (NSC) are multipotent, self-renewing cells that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated in response to metabolic and signalling changes, allowing for long-term continuous neurogenesis and response to injury. Ensuring a critical balance between quiescence and reactivation is required to maintain the limited NSC reservoir and neural replenishment throughout lifetime. The precise mechanisms and signalling pathways behind this balance are at the focus of current research. In this review, we highlight and discuss recent studies using Drosophila, mammalian and zebrafish models contributing to the understanding of molecular mechanisms underlying quiescence and reactivation of NSCs.},
language = {en},
number = {5},
urldate = {2026-03-11},
journal = {Biomolecules},
author = {Elkin, Adam M. and Robbins, Sarah and Barros, Claudia S. and Bossing, Torsten},
month = may,
year = {2025},
pages = {672},
}
@article{Grandel2006,
title = {Neural stem cells and neurogenesis in the adult zebrafish brain: {Origin}, proliferation dynamics, migration and cell fate},
volume = {295},
copyright = {https://www.elsevier.com/tdm/userlicense/1.0/},
issn = {00121606},
shorttitle = {Neural stem cells and neurogenesis in the adult zebrafish brain},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0012160606002478},
doi = {10.1016/j.ydbio.2006.03.040},
language = {en},
number = {1},
urldate = {2026-03-11},
journal = {Developmental Biology},
author = {Grandel, Heiner and Kaslin, Jan and Ganz, Julia and Wenzel, Isabell and Brand, Michael},
month = jul,
year = {2006},
pages = {263--277},
}
@article{Labusch2020,
title = {Conserved and {Divergent} {Features} of {Adult} {Neurogenesis} in {Zebrafish}},
volume = {8},
issn = {2296-634X},
url = {https://www.frontiersin.org/article/10.3389/fcell.2020.00525/full},
doi = {10.3389/fcell.2020.00525},
urldate = {2026-03-11},
journal = {Frontiers in Cell and Developmental Biology},
author = {Labusch, Miriam and Mancini, Laure and Morizet, David and Bally-Cuif, Laure},
month = jun,
year = {2020},
pages = {525},
}
