Speaker
Description
Ovarian epithelial cancer still claims the highest mortality rates of all \nobreakdash{gynaecological}
cancers to date, in part due to its complex tumour immune microenvironment (TIME) \cite{Veneziani2023}. The lymphocyte $\gamma\delta$ T cell subset has emerged as a promising target in cancer-related disease, such as ovarian carcinoma, due to its immunological plasticity \cite{Schadeck2024}. Cytotoxic properties of \mbox{$\gamma\delta$ T cells} can be enhanced using bi-specific antibodies, but are subjected to the modulation of other TIME components \cite{Gonnermann2020, Schadeck2024}. One key modulator is the immuno-suppressant galectin-3, which binds $\beta$-galactoside on the cell surface \cite{Gilson2019}. \
In this mathematical modelling approach, we develop a set of ordinary differential equations (ODE) which explores the system dynamics of $\gamma\delta$ T cells and galectin-3 in ovarian cancer. More specifically, we analyse characteristic T cell behaviour including exhaustion, proliferation and tumour cell killing by assessing the functional response models.
Bibliography
@article{Gilson2019,
author = {Gilson, Rebecca C. and Gunasinghe, Sachith D. and
Johannes, Ludger and Gaus, Katharina},
title = {Galectin-3 modulation of {T}-cell activation:
mechanisms of membrane remodelling},
journal = {Progress in Lipid Research},
year = {2019},
volume = {76},
pages = {101010},
doi = {10.1016/j.plipres.2019.101010},
note = {Epub 2019 Nov 1}
}
@article{Schadeck2024,
author = {Schadeck, Jan and Oberg, Hans-Heinrich and Peipp, Matthias and
Hedemann, Nina and Schamel, Wolfgang W. and
Bauerschlag, Dirk and Wesch, Daniela},
title = {{Vdelta1} {T} cells are more resistant than {Vdelta2} {T} cells
to the immunosuppressive properties of galectin-3},
journal = {Frontiers in Immunology},
year = {2024},
volume = {14},
pages = {1286097},
doi = {10.3389/fimmu.2023.1286097}
}
@article{Gonnermann2020,
author = {Gonnermann, Daniel and Oberg, Hans-Heinrich and Lettau, Marcus and
Peipp, Matthias and Bauerschlag, Dirk and Sebens, Susanne and
Kabelitz, Dieter and Wesch, Daniela},
title = {Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses
$\gamma\delta$ {T} Cell Proliferation but Not Their Cytotoxicity},
journal = {Frontiers in Immunology},
year = {2020},
volume = {11},
pages = {1328},
doi = {10.3389/fimmu.2020.01328}
}
@article{Veneziani2023,
author = {Veneziani, Ana C. and Gonzalez-Ochoa, Eduardo and
Alqaisi, Husam and Madariaga, Ainhoa and Bhat, Gita and
Rouzbahman, Marjan and Sneha, Suku and Oza, Amit M.},
title = {Heterogeneity and treatment landscape of ovarian carcinoma},
journal = {Nature Reviews Clinical Oncology},
year = {2023},
volume = {20},
pages = {820--842},
doi = {10.1038/s41571-023-00819-1},
publisher = {Springer Nature},
note = {Published: 02 October 2023}
}
