Speakers
Description
GLIMPRINT (the Global Alliance for Immune Prediction and Intervention) is a community advancing mechanistic modeling methods for infection and immune response, with the long-term goal of enabling immune digital twins—computational representations that connect biological mechanism to patient- and tissue-relevant predictions. This minisymposium highlights complementary multiscale approaches spanning sepsis and acute inflammation, fungal lung infection dynamics, T cell regulation and functional responses, and influenza infection with spatially explicit tissue-scale modeling. Across these applications, speakers emphasize principled links from molecular and cellular processes to tissue and organism-level outcomes, integration of experimental and clinical observations, and practical workflows for using models to interrogate disease trajectories and evaluate candidate interventions. Together, the talks illustrate how mechanistic multiscale immune modeling is maturing into actionable digital-twin approaches across diverse infectious and inflammatory contexts.
Bibliography
@article{wertheim_multi-approach_2021,
author = {Wertheim, Kenneth Y. and Puniya, Bhanwar Lal and La Fleur, Alyssa and Shah, Ab Rauf and Barberis, Matteo and Helikar, Tomáš},
title = {A multi-approach and multi-scale platform to model CD4$^{+}$ T cells responding to infections},
journal = {PLoS Computational Biology},
volume = {17},
number = {8},
pages = {e1009209},
year = {2021},
doi = {10.1371/journal.pcbi.1009209}
}
@misc{an_design_2024,
author = {An, Gary and Cockrell, Chase},
title = {A design specification for Critical Illness Digital Twins (CIDTs) to cure sepsis: responding to the National Academies of Sciences, Engineering and Medicine Report ``Foundational Research Gaps and Future Directions for Digital Twins''},
year = {2024},
eprint = {2405.05301},
archivePrefix = {arXiv},
note = {arXiv:2405.05301v2}
}
@article{ribeiro_multi-scale_2022,
author = {Ribeiro, Henrique Al and Vieira, Luis Sordo and Scindia, Yogesh and Adhikari, Bandita and Wheeler, Matthew and Knapp, Adam and Schroeder, William and Mehrad, Borna and Laubenbacher, Reinhard},
title = {Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome},
journal = {Journal of the Royal Society Interface},
volume = {19},
number = {189},
pages = {20210806},
year = {2022},
doi = {10.1098/rsif.2021.0806}
}
@article{laubenbacher_using_2021,
author = {Laubenbacher, Reinhard and Sluka, James P. and Glazier, James A.},
title = {Using digital twins in viral infection},
journal = {Science},
volume = {371},
number = {6534},
pages = {1105--1106},
year = {2021},
doi = {10.1126/science.abf3370}
}
