Description
This mini-symposium brings together researchers from different groups, from USA, Spain and France, all working on the mathematical modeling of telomere dynamics. It will give a unique opportunity to compare and discuss different approaches on close subjects : parameter inference of telomere length regulation in yeast (Viviana Gavilanes); stochastic models of telomere shortening and reconstruction, and their connections to carcinogenesis (Marek Kimmel) on the one hand, and on the emergence of ALT (Alternative Lengthening of Telomeres) survivors (Juan Mardomingo Sanz), a critical area for understanding cellular immortality on the other hand. Finally, Ana-María Portillo della Fuente will explore the role of oxidative stress in aging and its impact on female fertility, integrating modeling approaches with physiological outcomes.
Bibliography
@article{portillo2023influence,
title={Influence of telomerase activity and initial distribution on human follicular aging: Moving from a discrete to a continuum model},
author={Portillo, Ana M and Varela, Elisa and Garc{\'\i}a-Velasco, Juan A},
journal={Mathematical Biosciences},
volume={358},
pages={108985},
year={2023},
publisher={Elsevier}
}
@article{portillo2025influence,
title={Influence of oxidative stress on women’s fertility: A model with a generational age Caputo’s fractional derivative},
author={Portillo, AM and Garc{\'\i}a-Velasco, JA and Varela, E},
journal={BioSystems},
pages={105577},
year={2025},
publisher={Elsevier}
}
@article{benetos2024stochastic,
title={Stochastic branching models for the telomeres dynamics in a model including telomerase activity},
author={Benetos, Athanase and Fritsch, Coralie and Horton, Emma and Lenotre, Lionel and Toupance, Simon and Villemonais, Denis},
journal={arXiv preprint arXiv:2407.11453},
year={2024}
}
@article{lee2020analysis,
title={Analysis of two mechanisms of telomere maintenance based on the theory of g-Networks and stochastic automata networks},
author={Lee, Kyung Hyun and Kimmel, Marek},
journal={BMC genomics},
volume={21},
number={Suppl 9},
pages={587},
year={2020},
publisher={Springer}
}
@article{rat2025mathematical,
title={Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics},
author={Rat, Ana{\"\i}s and Martinez Fernandez, Veronica and Doumic, Marie and Teixeira, Maria Teresa and Xu, Zhou},
journal={Nature Communications},
volume={16},
number={1},
pages={1024},
year={2025},
publisher={Nature Publishing Group UK London}
}
