Speaker
Fenora David
(UCL)
Description
Tumour progression is shaped by a dynamic interaction between tumour cells and the immune system. One specific immunosuppressive mechanism to study tumour evasion causes cytotoxic T-cells, a major driving force of the immune system, to differentiate to an ‘exhaustive’ state where they have reduced immune effectiveness due to increased tumour interactions. While this is incorporated in existing mathematical models, we now extend this framework by introducing a doubly structured tumour-immune model in which tumour cells are additionally structured by accumulated damage due to immune attacks. Initially considering binary structure variables helps us build intuition, before then examining larger compartment numbers towards the continuum limit.
Authors
Fenora David
(UCL)
Helen M. Byrne
(University of Oxford)
Benjamin J Walker
(UCL)
