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Description
Background: Neural power spectra contain an aperiodic $\frac{1}{f^\alpha}$ background and superimposed oscillatory peaks, but conventional band-power metrics do not separate these contributions. The FOOOF (Fitting Oscillations & One-Over-F) algorithm \cite{1} provides a parametric decomposition of both components, enabling analysis of spectral features associated with distinct physiological processes. Here, we apply this framework to electroencephalographic (EEG) recordings during emergence from general anesthesia.
Methods: We retrospectively analyzed frontal EEG recordings from 306 patients previously classified into six emergence trajectories based on alpha and delta power \cite{2}. Absolute and relative alpha and delta power were calculated and the FOOOF algorithm was applied to extract the spectral exponent and alpha peak height. All spectral metrics were time-normalized to allow group-level comparisons.
Results: Mapping the emergence trajectories in the alpha-delta plane revealed trajectory-specific patterns, however, they lacked convergence at emergence endpoints. In contrast, FOOOF-derived parameters demonstrated a progressive flattening of the spectral exponent and a decrease in alpha peak height across all trajectories.
Conclusion: While alpha and delta power distinguish emergence trajectories, the spectral exponent consistently tracks neurophysiological transitions during anesthesia emergence, suggesting a trajectory-independent marker of awakening dynamics.
Bibliography
@article{1,
title={Parameterizing neural power spectra into periodic and aperiodic components},
author={Donoghue, Thomas and Haller, Matar and Peterson, Erik J and Varma, Paroma and Sebastian, Priyadarshini and Gao, Richard and Noto, Torben and Lara, Antonio H and Wallis, Joni D and Knight, Robert T and others},
journal={Nature neuroscience},
volume={23},
number={12},
pages={1655--1665},
year={2020},
publisher={Nature Publishing Group US New York}
}
@article{2,
title={Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications},
author={Hesse, S and Kreuzer, M and Hight, D and Gaskell, A and Devari, P and Singh, D and Taylor, NB and Whalin, MK and Lee, S and Sleigh, JW and others},
journal={British journal of anaesthesia},
volume={122},
number={5},
pages={622--634},
year={2019},
publisher={Elsevier}
}
