Speaker
Description
Molecular glues are small molecules that enable targeting of previously “undruggable” proteins by promoting interactions between a protein of interest (POI) and an effector protein, leading either to stabilization or degradation of the target. Despite increasing interest in these systems, the kinetic mechanisms governing their performance remain poorly understood.
We develop a mathematical framework describing the dynamics of molecular glue–mediated ternary complex formation and downstream effects. Model analysis reveals key determinants that shape system behavior and highlights how kinetic parameters and component abundances influence activity. The framework further provides quantitative insight into potential design principles for optimizing molecular glue strategies.
