Speaker
Description
There are many instances in cell biology, and in cell signalling in particular where non-monotonic dose responses are encountered, and these have important biological and physiological implications. In this presentation we dissect biphasic responses at the basic biochemical level, at the network level and in concrete cell signalling systems. At the basic biochemical level we explore a variety of systems which are extensions of covalent modification cycles (eg cascades, substrate modification sequences), with different degrees of commonality of enzymes and/or substrates. We uncover when these system are capable of enzyme-biphasic (biphasic responses to change in total enzyme amount) and substrate biphasic (biphasic responses to change in substrate amount. We determine when biphasic responses will and will not be possible (in the latter case independent of parameters). We then explore the effect of biphasic effects in regulation in networks. Finally we also the presence of enzyme biphasic and substrate biphasic responses in concrete exemplar signalling systems. Overall through a combination of analytical and computational work, we uncover a diversity of sources of biphasic responses, how they combine and how they impact systems behaviour.
Bibliography
@article{ref1,
title={A unified approach to dissecting biphasic responses in cell signalling},
author={Ramesh, Vaidhiswaran and Krishnan, J},
journal={eLife},
volume={12},
pages={e86520},
year={2023},
publisher={eLife Sciences Publications, Ltd}
}
