Speaker
Description
Oral squamous cell carcinoma (OSCC) represents the vast majority of oral cancers and is associated with high mortality. Patients with Oral Potentially Malignant Disorders (OPMD) present a risk of developing OSCC, and identifying OPMD with a high risk of malignant transformation remains a critical clinical issue.
Macrophages constitute a major immune population infiltrating the tumor microenvironment during carcinogenesis. Previous studies have reported conflicting results on the impact of M2 macrophages enrichment in the risk of OPMD malignant transformation. Bouaoud, Foy et al.~\cite{bouaoud_early_2021} found a positive association between M2 macrophages enrichment and oral cancer-free survival in OPMD.
In this work, we perform immune deconvolution and gene set enrichment analyses using OPMD gene expression data. Then we build a system of two phenotypically-structured partial differential equations describing two cell populations : epithelial cells and macrophages. Numerical results with various parameter configurations, together with data-fitted model outputs, provide biological insights with the perspective of gaining a better understanding of the drivers of OPMD malignant transformation.
Bibliography
@article{bouaoud_early_2021,
title = {Early changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of {M2} macrophages with oral cancer free survival},
volume = {10},
issn = {2162-402X},
url = {https://www.tandfonline.com/doi/full/10.1080/2162402X.2021.1944554},
doi = {10.1080/2162402X.2021.1944554},
language = {en},
number = {1},
urldate = {2026-03-15},
journal = {OncoImmunology},
author = {Bouaoud, J. and Foy, J.-P. and Tortereau, A. and et, al.},
month = jan,
year = {2021},
pages = {1944554},
}
