12–17 Jul 2026
University of Graz
Europe/Vienna timezone

From Dilution to Amplification: Modeling Host-Driven Transitions in Lyme Disease

16 Jul 2026, 11:40
20m
15.21 - SZ (University of Graz)

15.21 - SZ

University of Graz

90
Contributed Talk Mathematical Epidemiology Contributed Talks

Speaker

Vardayani Ratti (California State University Sacramento)

Description

We develop and analyze a temperature-driven, stage-structured model for the transmission of Borrelia burgdorferi (Lyme disease) involving the tick vector Ixodes scapularis and multiple host classes. The model is formulated as a system of nonlinear ordinary differential equations incorporating seasonal forcing, life-stage transitions, and host-dependent feeding dynamics.

We compare two formulations: one with density-based host contact and one with stage-dependent host preference. Using numerical simulations, we examine how variations in reservoir-competent and reservoir-incompetent host populations influence both tick abundance and infection dynamics.

Our results demonstrate that host preference significantly alters system behavior and leads to a threshold-type phenomenon: a dilution effect occurs at low densities of reservoir-competent hosts, while an amplification effect emerges at higher densities. These findings highlight the role of host composition in shaping disease dynamics and provide a mechanistic explanation for contrasting outcomes reported in the ecological literature.

Authors

Vardayani Ratti (California State University Sacramento) Dorothy Wallace (Dartmouth College)

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