Speaker
Description
This study uses vertex- and Voronoi-based computational models based on Chaste \cite{Cooper2020} to investigate interclonal cooperation within cell populations. We analyze interactions between mutated cell types with distinct hyperproliferative and invasive properties. Modeling the cooperative dynamics among these clones shows how cellular heterogeneity affects tissue growth and invasion, enhancing the understanding of tumor progression and therapeutic target predictions.
Bibliography
@article{Cooper2020,
title = {Chaste: Cancer, Heart and Soft Tissue Environment},
author = {Cooper, Fergus R. and Baker, Ruth E. and Bernabeu, Miguel O. and Bordas, Rafel and Bowler, Louise and Bueno-Orovio, Alfonso and Byrne, Helen M. and Carapella, Valentina and Cardone-Noott, Louie and Cooper, Jonathan and Dutta, Sara and Evans, Benjamin D. and Fletcher, Alexander G. and Grogan, James A. and Guo, Wenxian and Harvey, Daniel G. and Hendrix, Maurice and Kay, David and Kursawe, Jochen and Maini, Philip K. and McMillan, Beth and Mirams, Gary R. and Osborne, James M. and Pathmanathan, Pras and Pitt-Francis, Joe M. and Robinson, Martin and Rodriguez, Blanca and Spiteri, Raymond J. and Gavaghan, David J.},
journal = {Journal of Open Source Software},
year = {2020},
volume = {5},
number = {47},
pages = {1848},
doi = {10.21105/joss.01848}
}
