Speaker
Description
Tumor progression depends not only on the intrinsic characteristics of the cancerous cells but also on the bidirectional complex interactions within the tumor microenvironment. Among these interactions, lymphocytes, immune cells, play an important role \cite{SanchoAraiz2021}.
In this work, we will generalize the mathematical model developed by Sung et al. in \cite{Sung2020} for hepatocellular carcinoma to provide a more general framework applicable to a broad range of cancer types. This model describes the stimulating effect of malignant cells on the immune system as well as the immunosuppressive effects of radiotherapy. We will study the dynamics of the model, detailing the equilibrium points of the system and the conditions needed for them to be feasible. We will also present numerical simulations to validate the theoretical results and illustrate the behavior of the system under different radiotherapy fractionation schedules.
Bibliography
@article{Sung2020,
author = "Sung, W. and Grassberger, C. and McNamara, A. L. and Basler, L. and Ehrbar, S. and Tanadini-Lang, S. and Hong, T. S. and Paganetti, H.",
title = "A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy",
journal = "Radiotherapy and Oncology",
volume = "151",
pages= "73--81",
year = "2020",
url = "https://doi.org/10.1016/j.radonc.2020.07.025",
doi = "10.1016/j.radonc.2020.07.025"
}
@article{SanchoAraiz2021,
title = {The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives},
volume = {13},
ISSN = {1999-4923},
url = {http://dx.doi.org/10.3390/pharmaceutics13071016},
DOI = {10.3390/pharmaceutics13071016},
number = {7},
journal = {Pharmaceutics},
publisher = {MDPI AG},
author = {A. Sancho-Araiz, V. Mangas-Sanjuan, I. F. Trocóniz},
year = {2021},
month = jul,
pages = {1016}
}
