Speaker
Tracy Stepien
(University of Florida)
Description
During gastrulation, an early stage of embryonic development, cell migration is crucial for the formation of germ layers that eventually develop into tissues and organs. We develop a continuum mechanical model of dual layer cell migration during gastrulation that includes intercalation of cells between the mesenchymal and epithelial cell layers. Approximate Bayesian computation with sequential Monte Carlo (ABC-SMC) and sensitivity analysis are used to obtain parameter estimates and to compare between various model formulations. A goal of this work is to determine the functional form of intercalation and cell layer growth that best reflects the experimental data from spreading aquatic frog Xenopus laevis tissue.
Author
Tracy Stepien
(University of Florida)
Co-authors
Holley Lynch
(Stetson University)
Lance Davidson
(University of Pittsburgh)
Sanandan Ojha
(University of Florida)
