Speaker
Description
Population pharmacokinetic (PPK) modeling, as presented in \cite{ette2004population1} and \cite{mould2012basic}, offers a systematic approach for quantifying inter-individual variability and estimating population parameters in PK-PD models. Within this framework, co-variate effects on the pharmacokinetic parameters of the Schnider PK-PD model \cite{schnider1998influence}, commonly implemented in target controlled infusion (TCI) infusion pumps for anesthesia, are examined. This helps identify key patient-specific parameters to simulate the concentration-time profile of individual patients as accurately as possible since the overall goal is to improve individualized anesthesia.
Particular emphasis is placed on the central compartment volume $V1$ and the initial phase of drug administration, as the overarching aim is to prevent an overshoot at the onset of the infusion in the simulation of TCI pumps. Based on the estimated population parameters, an adapted model is developed in which the central volume $V1$ is scaled according to the significant co-variates height and gender, which were selected using a backward co-variate screening procedure. Compared to the original Schnider model, the adapted model demonstrates substantial improvement, particularly in its ability to more accurately represent high concentration levels.
Bibliography
@article{schnider1998influence,
title={The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers},
author={Schnider, Thomas W and Minto, Charles F and Cambus, PL and Andresen, Corina and Goodale, David B and Shafer, Steven L and Youngs, Elizabeth J},
journal={ANESTHESIOLOGY-PHILADELPHIA THEN HAGERSTOWN-},
volume={88},
pages={1170--1182},
year={1998},
publisher={JB LIPPINCOTT CO}
}
@article{ette2004population1,
title={Population pharmacokinetics I: background, concepts, and models},
author={Ette, Ene I and Williams, Paul J},
journal={Annals of Pharmacotherapy},
volume={38},
number={10},
pages={1702--1706},
year={2004},
publisher={SAGE Publications Sage CA: Los Angeles, CA}
}
@article{mould2012basic,
title={Basic concepts in population modeling, simulation, and model-based drug development},
author={Mould, Diane R and Upton, Richard N},
journal={CPT: pharmacometrics \& systems pharmacology},
volume={1},
number={9},
pages={1--14},
year={2012},
publisher={Wiley Online Library}
}
