12–17 Jul 2026
University of Graz
Europe/Vienna timezone

Entropy-Based Information Sharing for Uncertainty Quantification in Multi-Layer Complex Systems

MS26-01
16 Jul 2026, 10:40
20m
02.23 - HS (University of Graz)

02.23 - HS

University of Graz

112
Minisymposium Talk Numerical, Computational, and Data-Driven Methods MBI Community Gathering: Emerging Methods and Mathematical Models Arising from Biology

Speaker

Grzegorz Rempala (Ohio State)

Description

We propose an entropy-based framework for uncertainty quantification in settings involving multiple, heterogeneous data sources. The central idea is to represent each empirical layer through an entropy-induced probability measure, allowing information to be shared and propagated across layers in a principled and consistent manner. This approach provides a natural mechanism for reconciling uncertainty arising from observational, experimental, and model-based components, while enabling interpretable variance–covariance decompositions analogous to ANOVA.

As an illustrative example, we reference recent work on random-measure-based sensitivity analysis in randomized controlled trials (Bastian, Rabitz, and Rempala, 2025), where entropy-consistent measures are used to quantify and decompose uncertainty across treatment and outcome spaces. While arising in a clinical context, this example highlights the broader applicability of entropy-driven information sharing for uncertainty quantification in complex, multi-layer systems.

Author

Grzegorz Rempala (Ohio State)

Presentation materials

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