Speaker
Description
Influenza A virus infections are a major cause of human morbidity and mortality worldwide. A key aspect of the immune response, bridging innate and adaptive immunity, is the role of interferons. Here, we present experimental data identifying the primary producers of Type II interferon and providing novel insights into production rates via the integrated Median Fluorescence Intensity. This approach offers a new modelling opportunity, allowing us to quantify production rates at the population level and uncover production and binding mechanisms that would likely be overlooked from population data alone. Building on these insights, we present a novel viral dynamics model that incorporates Type II interferon production and binding. Using this framework, we investigate how interferon responses may be associated with infection severity and consider potential binding mechanisms that could contribute to this relationship.
