European Conference on Mathematical and Theoretical Biology (ECMTB 2026)

How Random Forces Help Rather Than Hinder Dynein Cargo Transport

MS45-04

16 Jul 2026, 15:50

20m

15.06 - HS (University of Graz)

Minisymposium Talk Numerical, Computational, and Data-Driven Methods Data-driven modeling in biology and medicine

Speaker

John Dallon (Department of Mathematics, Brigham Young University, Provo UT, USA)

Description

Recent experimental work has shown that dynein transports cargo faster in vivo than in vitro, although counter intuitive, the results are consistent with other experimental data \cite{Torisawa:2025:AFC}. Typically, it is assumed that the cytoplasm, a more viscous and complex environment, should slow down transport compared to in vitro experiments. It is postulated that the catch bond nature of dynein allows this counter intuitive result. In this talk I will discuss a stochastic tug-of-war model of dynein transport that sheds light on this phenomena.

Bibliography

@article{Torisawa:2025:AFC,
author = {Torisawa, Takayuki and Saito, Kei and Furuta, Ken'ya and Kimura, Akatsuki},
journal = {iScience},
number = {114096},
title = {Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven intracellular transport along microtubules},
volume = {28},
year = {2025}}