European Conference on Mathematical and Theoretical Biology (ECMTB 2026)

Mechanistic Learning of Engineered Immune Cell-Tumor Cell Interactions and Heterogeneity

MS48-07

14 Jul 2026, 18:00

20m

62.01 - HS (University of Graz)

Minisymposium Talk Mathematical Oncology Models and Methods for the Analysis of Cancer Treatment

Speaker

Philipp Altrock (Cancer Modeling & Evolution UKSH Campus Kiel)

Description

Chimeric Antigen Receptor (CAR) T-cell therapy has emerged as a promising option for relapsed or refractory lymphoma patients and acute leukemias. Mathematical modeling offers a valuable tool for investigating the interactions among these living drugs, tumors, and heterogeneous patients' immune or inflammatory context. Using longitudinal data from experiments and the clinic, we examine how diverse CAR T cell phenotypes interact with heterogeneous tumors, how these interactions can be inferred, and how they impact outcomes.