Speaker
Description
The tumor microenvironment is a complex system involving cross-talk between tumor cells, stromal cells, and therapeutics in the microenvironment. One major avenue of my research has been the interactions between cancer cells, immunotherapy, and immune cells. In order to examine this, we developed an agent-based model that examines the interplay between cancer cells and their surrounding host environment, including blood vessels, hypoxia, therapeutics, and immune cells. This talk will look at the various computational models that examine tumor therapeutics and the tumor microenvironment. This will include monotherapies such as anti-angiogenesis therapies, salinomycin, T-cell therapy, and macrophage polarity as well as combination therapies. This type of modeling allows us to predict under which conditions immunotherapy would be most successful under different assumptions.
