Speaker
Description
This talk focuses on the mathematical modeling of oncolytic virotherapy (OVT), based on joint work with T. Hillen. We begin with a qualitative analysis of an extended model that captures the interactions between tumor cells, viruses, and the immune system. Building on this foundation, we investigate strategies to improve treatment efficacy, showing through analysis and simulations that combination therapies and optimized protocols can significantly outperform monotherapy approaches. A central theme of this work is the emergence and role of travelling wave solutions, which describe the spatial spread of infection and its interaction with both the tumor and the immune response. We present numerical evidence of complex wave dynamics and establish their existence rigorously using analytical techniques.
