Speaker
Description
Eye drops are typically used to deliver ophthalmic drugs that treat both acute and chronic eye disorders such as glaucoma. However, drugs delivered by this method quickly leave the tear film due to blinking and drainage. In contrast, drug-eluting contact lenses allow the drug to remain in the tear film much longer, thus serving as a potential drug delivery vehicle. Recently, such lenses have been designed by encapsulating drug-polymer films in contact lens hydrogels, where the drug-laden region takes an annular shape when viewed from the top down. Informed by in vivo data, we design a coupled partial differential equation three-layer model of contact lens drug release to mathematically investigate the effect of lens design characteristics on the time to 50% drug release (t50) in the vial, blister pack, and eye settings. In the eye setting, we incorporate our prior model that considers the effect of many blinks on the pre- and post-lens tear film drug concentrations. We simulate drug cumulative release profiles and study the variability of t50 across: (1) the ratio of the hydrogel to drug-polymer film diffusion coefficients, (2) the centerline of the polymer within the hydrogel, and (3) the polymer thickness. This work may help medical professionals better understand the mechanics of contact lens drug delivery and predict targeted tissue transport of drug.
Bibliography
@article{anderson2024mathematical,
title={Mathematical models of drug delivery via a contact lens during wear},
author={Anderson, Daniel M and Luke, Rayanne A},
journal={La Matematica},
volume={3},
number={4},
pages={1510--1564},
year={2024},
publisher={Springer}
}
@article{ross2019topical,
title={Topical sustained drug delivery to the retina with a drug-eluting contact lens},
author={Ross, Amy E and Bengani, Lokendrakumar C and Tulsan, Rehka and Maidana, Daniel E and Salvador-Culla, Borja and Kobashi, Hidenaga and Kolovou, Paraskevi E and Zhai, Hualei and Taghizadeh, Koli and Kuang, Liangju and others},
journal={Biomaterials},
volume={217},
pages={119285},
year={2019},
publisher={Elsevier}
}
