European Conference on Mathematical and Theoretical Biology (ECMTB 2026)

Automatic initial estimates of reaction rate coefficients

MS112-05

17 Jul 2026, 10:40

20m

11.03 - HS (University of Graz)

Minisymposium Talk Systems Biology and Biochemical Networks Reaction networks: Mathematical structures and concrete biochemical systems

Speaker

János Tóth (Eötvös Loránd University Budapest)

Description

Fitting functions to data with nonlinear parameter dependence is challenging, particularly for differential equations common in chemical kinetics, due to the need for good initial estimates. We propose a method to automatically generate robust initial estimates for mass-action kinetic ODEs (where the right-hand side is linear in parameters). Illustrative examples show these estimates often yield highly accurate final fits.

Bibliography

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