Speaker
Description
Cardiac pulsed field ablation (PFA) is an emerging non-thermal ablation modality that employs high-intensity, short-duration electric pulses to induce irreversible electroporation in cardiac cells. In contrast to conventional thermal techniques, PFA selectively disrupts cell membranes while largely preserving the extracellular matrix and surrounding critical structures, thereby reducing collateral damage. This selectivity, combined with rapid energy delivery, enabled the quick adoption PFA for the treatment of many types of cardiac arrhythmia.
In this work, we present a multiscale modeling framework that links cellular electroporation dynamics to tissue-level lesion formation in cardiac PFA. At the cell level, the model captures pore generation, membrane oxidation, and the resulting changes in cellular permeability and electrical conductivity in response to the evolution throughout the temporal progression of the electric pulses. At tissue level, these cellular responses are integrated into a bidomain formulation to predict lesion development. The proposed time-dependent multiscale framework accounts for physiological tissue responses during and after the delivery of the pulses, and is capable of simulating PFA-induced lesion formation along time.
