Speaker
Description
Understanding nutrient transport is essential for mathematically modelling bacterial functions because transport processes govern the rates at which cells acquire substrates that fuel all downstream metabolic activity. Nutrient uptake directly shapes intracellular metabolite levels and thereby constrains metabolic pathway fluxes.
Some data driven mathematical approaches to model membrane nutrient transport and metabolic flow are explored. These model building blocks need to be scoped for different levels of biophysical specificity to enable future hybrid modelling and incorporation into whole cell models.
Techniques to identify inconsistencies between models, observations, and the data itself are discussed, and illustrate how mathematical modelling can guide experimental interpretation.
