Ocular hypertension can arise when the conventional outflow route for the aqueous humor of the eye becomes partially blocked, leading to an increase in interocular pressure (IOP) with associated risk of developing Glaucoma. Increasing the unconventional outflow route is a potential mechanism to decrease IOP, and certain types of Minimally Invasive Glaucoma Surgery (MIGS) are designed to...
Age-related macular degeneration (AMD) is a primary cause of irreversible vision loss worldwide, causing years of progressive visual decline and reduced quality of life that may culminate in severe visual impairment or blindness. Available therapeutic options are limited to late-stage disease, when irreversible damage to ocular tissues has already occurred and patients experience significant...
The corneal epithelium is a self-renewing tissue maintained with remarkable precision. Its regeneration is driven by limbal epithelial stem cells (LESCs), which reside at the corneal periphery and give rise to transit amplifying cells (TACs) that migrate centripetally toward the centre. These TACs continually replenish the tissue and, together with vertical delamination between layers, sustain...
Wet age-related macular degeneration is a chronic ocular disease treated by repeated intravitreal injections. The relatively short intravitreal half-life of these therapeutics leads to frequent administration, creating a substantial treatment burden. Accurate estimation of the effective diffusion coefficient is central to predicting intravitreal half-life and to the rational design of...
Vision loss and ocular disease constitute major global health challenges. In recent years, mathematical ophthalmology has experienced substantial growth and increasing acceptance within the clinical and biomedical communities, driven by advances in ocular imaging, experimental measurement, and the availability of high-quality clinical and preclinical data.
This mini-symposium will highlight...
