Understanding how the tumor microenvironment influences interactions between tumor cells and the immune system is a major question in mathematical oncology. In particular, the spatial organization of nutrient sources and immune cell recruitment may strongly affect tumor progression and immune control.
In this work, we study this question using a continuum mixture model describing...
Malignant pleural mesothelioma (MPM) is an aggressive tumour associated with poor prognosis and limited treatment options, motivating the investigation of novel therapeutic approaches. Among these, chimeric antigen receptor (CAR)–based adoptive cell immunotherapy has attracted considerable interest due to its potential to achieve durable clinical responses
We combine experimental and...
We present a continuous model describing the interplay between tumour mass and the immune system. Building on \cite{carrillo2019population}, we incorporate a nonlocal formulation that captures adhesion and chemoattraction forces at the microscopic level.
We investigate how the proliferation–immune susceptibility trade-off can be calibrated, identifying which balance between rapid growth...
Malignant gliomas (MGs) remain highly resistant to conventional treatments. We propose an ordinary differential equation model to investigate the potential synergistic dynamics between standard therapy (radiotherapy (RT) and temozolomide (TMZ)) \cite{Stupp} and chimeric antigen receptor (CAR) T-cell therapy \cite{Brown}. While both TMZ and RT can be lymphotoxic, TMZ may also enhance CAR T...
Tumour growth arises from a complex interplay between cancer cells and their microenvironment, often facilitated by failure of the immune system to effectively control malignant cells. Over the past decades, several immunotherapeutic approaches have been developed to enhance the anti-tumour immune response by harnessing the body’s natural immune defences to fight cancer. However, the design...
