Understanding how to safely shorten antibiotic treatment for tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is a critical step towards eradicating the world's leading cause of death by single infectious pathogen. Many patients need three months of antibiotic treatment or less, though shortening the recommended treatment duration is dangerous as we cannot predict...
Engineered T cell receptor T cells (TCR-T) are intended to drive strong anti-tumor responses upon recognition of the specific cancer antigen, resulting in rapid expansion in the number of TCR-T cells and enhanced cytotoxic functions, causing cancer cell death. Although TCR-T cell therapy against cancers has shown promising results, it remains difficult to predict which patients will benefit...
By coupling omics‑derived cell states to ABMs of PDAC ecosystems, this work develops a new in silico framework that can systematically investigate the implication of candidate antigen presentation and T cell activation mechanisms in the microenvironment from PDAC spatial multi-omics data, allowing us to better understand the interplay of pro-activation and pro-tolerance signals experienced by...
T cell exhaustion is a dysfunctional state that develops after prolonged antigen exposure, in which T cells progressively lose effector function. Exhaustion is marked by the sustained expression of inhibitory receptors which transmit suppressive signals that limit immune activity. Recent studies indicate that the 24 hour period after initial antigen exposure is a critical window in the...
We propose a minisymposium highlighting recent advances in mathematical and computational modeling of the immune response to therapy in the context of chronic diseases. Disease-associated chronic antigen exposure induces an immune response characterized by sustained activation followed by progressive functional decline of immune cells. Therapeutic interventions must therefore overcome not only...
