Speakers
Description
This mini-symposium gathers four researchers to explore the mathematical foundations of ageing, evolutionary selection, and cell physiology, bridging theory and biological applications.
Sarah Kaakai investigates how age-structured populations could cross fitness valleys.
Sylvie Méléard presents a scenario for the evolutionary selection of ageing, using a life-history trait model to demonstrate the convergence of fertility and senescence. Her work suggests that ageing could be an adaptive force, improving genetic variability and evolutionary success.
Luce Breuil introduces a coupled system of age-structured partial differential equations to model two-phase ageing in D. melanogaster. By analyzing well-posedness, stability, and global asymptotic behavior, she explores the evolutionary advantages of discontinuous ageing and its implications for population dynamics.
Alexandre Perrin shifts focus to E. coli, employing mathematical models to study DNA replication, cell division, and antibiotic response.
Bibliography
@article{roget2024scenario,
title={A scenario for an evolutionary selection of ageing},
author={Roget, Tristan and Macmurray, Claire and Jolivet, Pierre and Meleard, Sylvie and Rera, Michael},
journal={Elife},
volume={13},
pages={RP92914},
year={2024},
publisher={eLife Sciences Publications Limited}
}
@article{perrin2025deciphering,
title={Deciphering the Replication-Division Coordination in E. coli: A Unified Mathematical framework for Systematic Model Comparison},
author={Perrin, Alexandre and Doumic, Marie and El Karoui, Meriem and M{\'e}l{\'e}ard, Sylvie},
journal={bioRxiv},
pages={2025--07},
year={2025},
publisher={Cold Spring Harbor Laboratory}
}
@article{meleard2019birth,
title={A birth--death model of ageing: from individual-based dynamics to evolutive differential inclusions},
author={M{\'e}l{\'e}ard, Sylvie and Rera, Michael and Roget, Tristan},
journal={Journal of mathematical biology},
volume={79},
number={3},
pages={901--939},
year={2019},
publisher={Springer}
}
