Despite extensive research, the quantitative principles that govern the coordination between DNA replication and cell division in bacteria remain debated. Multiple theoretical models have been proposed, some postulating that a single regulatory process is sufficient to ensure replication–division coordination, while others argue that two concurrent processes are required for robust control. To...
Ageing’s sensitivity to natural selection has long been discussed because of its apparent negative effect on an individual’s fitness. Thanks to the recently described (Smurf) 2-phase model of ageing (data of Michael Rera) we propose a fresh angle for modeling the evolution of ageing. Indeed, by coupling a dramatic loss of fertility with a high-risk of impending death—amongst other multiple...
Recent biological evidence suggests the presence of a 2-phase ageing process in D. Melanogaster. Following these discoveries, we first introduce a stochastic individual-based model and estimate from data the rates of transition between phases.
We then consider a deterministic approximation of the individual model to model an interacting population. We introduce a system of coupled...
The presence of older individuals in natural populations raises critical evolutionary questions: what influence do these individuals exert on population evolution? An example is the so-called Lansing effect, a transgenerational mechanism in which offspring born to older parents have shorter lifespans than those born to younger parents. This phenomenon has been observed across multiple species,...
This mini-symposium gathers four researchers to explore the mathematical foundations of ageing, evolutionary selection, and cell physiology, bridging theory and biological applications.
Sarah Kaakai investigates how age-structured populations could cross fitness valleys.
Sylvie Méléard presents a scenario for the evolutionary selection of ageing, using a life-history trait model to...
