Speakers
Description
Reinfection plays a central role in dengue dynamics, as secondary infection with a different serotype may lead to severe forms such as Dengue Hemorrhagic Fever (DHF) through Antibody-Dependent Enhancement (ADE). We propose a multi-scale nested immuno-epidemiological model coupling within-host immune dynamics and between-host transmission. The model accounts for primary and secondary infections, capturing the interplay between immunity and epidemiological spread \cite{Adimy2026Dengue}. We show the occurrence of backward bifurcation, implying that the basic reproduction number alone does not ensure disease eradication. We also derive an invasion reproduction number characterizing the ability of a new serotype to invade a population where another is endemic. These results highlight the underlying complexity of dengue reinfection dynamics and the role of ADE in shaping transmission and disease severity.
Bibliography
@article{Adimy2026Dengue,
author = {Adimy, M. and Dugourd-Camus, C. and Taieb, R.},
title = {Multi-serotype nested immuno-epidemiological model for dengue hemorrhagic fever involving backward bifurcation and serotype invasion},
journal = {Discrete and Continuous Dynamical Systems - B},
year = {2026},
doi = {10.3934/dcdsb.2026028}
}
