Flavescence dorée is one of the most severe phytoplasma diseases affecting grapevines, posing an increasing threat to vineyards worldwide. The bacterial agent causing the disease is spread by the American grapevine leafhopper. We present a compartmental model for the spread of flavescence dorée incorporating stage structure in the vectors. To account for seasonal weather variations and the...
The transmission of infectious diseases involves complex interactions across multiple biological scales, from within-host immunological processes to between-host transmission dynamics. We develop a multiscale epidemic model linking host--vector population-level transmission dynamics to within-host and within-vector pathogen dynamics. Our model captures key features of within-vector viral...
Reinfection plays a central role in dengue dynamics, as secondary infection with a different serotype may lead to severe forms such as Dengue Hemorrhagic Fever (DHF) through Antibody-Dependent Enhancement (ADE). We propose a multi-scale nested immuno-epidemiological model coupling within-host immune dynamics and between-host transmission. The model accounts for primary and secondary...
In this talk, we discuss the relationship between mosquito population dynamics and dengue fever case counts. Drawing on data from a specific city in Brazil, we analyze the primary drivers of dengue outbreaks and demonstrate that mosquito population dynamics alone are not a reliable predictor of outbreaks. Instead, climatic factors and the immunological status of the population appear to be the...
This mini-symposium explores the mathematical modeling of vector-borne diseases and their connection to potential epidemic drivers. Vector-borne diseases pose significant challenges to modeling approaches, as the ecological effects of the vector—intertwined with climatic drivers—play critical roles. In the case of dengue fever, which is caused by four different serotypes with incomplete...
