Speaker
Description
Suppressive antiretroviral therapy (ART) has been shown to only partially mitigate biological aging by plasma proteomic clocks in people living with HIV (PLWH). Despite effective viral suppression, treated individuals exhibit a measurable increase in biological age relative to uninfected controls, with more pronounced effects reported in younger populations.
In this talk, an eight-compartment ordinary differential equation (ODE) model is presented, in which a three-stage HIV viral dynamics sub-model is coupled with a long-lived cell (LLC) reservoir. This reservoir comprises tissue-resident macrophages and memory CD4+ T cell populations and is further linked to chronic inflammation, cellular senescence, and cumulative biological age advancement, denoted by Δ(t).
Mathematical analysis indicates that post-ART inflammatory decay is governed by the LLC reservoir half-life and that residual biological age accumulation is directly proportional to the reservoir size at treatment initiation. Under this framework, ART initiation at year 2 results in an estimated age advancement of Δ = 1.37 years, and initiation at year 4 yields Δ = 3.81 years. These results quantify the cumulative biological cost associated with delayed treatment initiation.
