Speakers
Description
The cardiovascular and ocular systems are intricately connected, with hemodynamic interactions playing a crucial role in both physiological regulation and pathological conditions. However, existing models often treat these systems separately, thus limiting the understanding of their interdependence.
This talk presents the Eye2Heart model, which is a novel closed-loop mathematical framework that integrates cardiovascular and ocular dynamics \cite{eye2heart}. Using an electrical-hydraulic analogy, the model describes the interactions between the heart and retinal circulation through a nonlinear system of ordinary differential equations. The model is tested against clinical and experimental data, thus demonstrating its ability to reproduce key cardiovascular parameters (e.g., stroke volume, cardiac output) and ocular hemodynamics (e.g., retinal blood flow). Additionally, we explore in silico the effects of intraocular pressure and left ventricular compliance on both local ocular and global systemic circulation, thus revealing critical dependencies between cardiovascular and ocular health. The results highlight the model’s potential for studying cardiovascular diseases with ocular manifestations and support emerging research in oculomics by providing a mechanistic basis to interpret ocular biomarkers within a systemic context.
Bibliography
@article{eye2heart,
title={Eye2Heart: A reduced mathematical model bridging cardiovascular and ocular hemodynamics},
author={Sala, Lorenzo and Zaid, Mohamed and Hughes, Faith and Szopos, Marcela and Huxley, Virginia H and Harris, Alon and Guidoboni, Giovanna and Lapin, Sergey},
journal={Mathematical Biosciences and Engineering},
volume={23},
number={2},
pages={421--448},
year={2026},
publisher={American Institute of Mathematical Sciences} }
