The cardiovascular and ocular systems are intricately connected, with hemodynamic interactions playing a crucial role in both physiological regulation and pathological conditions. However, existing models often treat these systems separately, thus limiting the understanding of their interdependence.
This talk presents the Eye2Heart model, which is a novel closed-loop mathematical framework...
Atherosclerotic plaques with similar luminal narrowing carry markedly different rupture risk, depending on fibrous-cap thickness, necrotic-core size, and the origin and maturity of intraplaque microvessels. We present a spatial agent-based model of a plaque-bearing arterial cross-section that couples the following mechanisms:
(i) hypoxia-driven foam-cell necrosis with variable efferocytic...
Cerebral autoregulation stabilizes cerebral blood flow despite changes in blood pressure through adjustments in arterial diameter. However, the precise roles of individual vessels and impaired autoregulation in outcomes after ischemic stroke remain poorly understood. We present a computational framework incorporating static myogenic and endothelial regulation in large semi-realistic...
Impaired cerebrovascular reactivity (CVR), the ability of cerebral blood vessel tone to respond to stimuli for regulating blood flow and metabolism in the brain, has been linked to many acute and chronic cardiovascular and neurological diseases. In one mechanism of cerebrovascular reactivity, the cerebral blood vessels dilate to lower resistance in response to increased arterial carbon dioxide...
Regulation of the dynamics of blood flow and pressure to, from, and within the brain is one of the most critical parts of sustaining human life. Disordered regulation in the cerebral (brain) vasculature has been associated with small vessel disease, stroke, brain tumors, traumatic brain injury, pharmaceutical use, and normal aging. In lieu of major illness, people with cerebrovascular...
