The hypothalamic-pituitary-thyroid (HPT) axis regulates endocrine feedback mechanisms essential for metabolic homeostasis. Mathematical models based on ordinary differential equations provide a framework for studying hormonal regulations. Nevertheless, the integration of physiological models with patient-specific clinical data continues to present significant challenges.
In this study, a...
The thyroid gland is an organ at risk (OAR) during head-and-neck radiotherapy (RT) due to its proximity to the treatment field. Ionising radiation can damage thyroid tissue, disrupt hormonal regulation by the hypothalamus-pituitary-thyroid (HPT) axis, and lead to endocrine dysfunction. Clinical studies report that 40-50% of patients develop hypothyroidism as a late RT-induced toxicity...
Control techniques that rely on a known model of the hypothalamic-pituitary-thyroid axis, such as model predictive control, have recently been explored for systematically recommending medication dosages to treat thyroid diseases like hypo- and hyperthyroidism \cite{A,B,C}. When implemented based on a high-fidelity model, they require knowledge of internal hormone concentrations of thyroid...
Graves' disease is an autoimmune thyroid disorder causing hyperthyroidism, with a lifetime risk of 3% in women and 0.5% in men, see \cite{A}. It is commonly treated with antithyroid drugs where current dosing guidelines still provide limited support for optimal dose selection as it is reported e.g. in \cite{B,C}. Strong inter-individual variability poses a major challenge for conventional...
The endocrine system is a highly complex feedback loop, making it difficult to model in order to gain insights into biological and medical processes, which are important for basic research in this field, the treatment of diseases and the optimal use of medication. This minisymposium will present methods for mathematically describing the hormonal processes of the Hypothalamus-Pituitary-Thyroid...
