Pulmonary tuberculosis (TB) remains a dire concern for countries across the globe, caused by inhaling Mycobacterium tuberculosis (Mtb). Granulomas, tissue-scale nodules that form within lungs of Mtb infected individuals, are hallmarks of human TB and are a central factor that complicates predictions of TB outcomes. Granulomas form in both lungs and lymph nodes (LNs) of pulmonary TB patients,...
Nontuberculous mycobacteria (NTM) lung infection is increasing in prevalence globally
and remains difficult to treat in part due to varied disease presentation and prognosis.
Some patients experience stable symptoms and require observation and bronchial
hygiene treatment; other patients will demonstrate disease progression symptomatically
and radiographically, requiring antibiotic...
Within host mathematical modelling has become central to understanding the complex, multiscale biology of Mycobacterium tuberculosis infection. This talk will synthesise the major modelling frameworks that have shaped the field, from early ordinary differential equation models to agent based, hybrid, and multiscale approaches linking molecular to systemic processes. We highlight core...
The BCG vaccine remains the only licensed vaccine against tuberculosis (TB), yet its protective efficacy is highly variable, and the mechanisms behind BCG-induced protection remain poorly understood. Plumlee et al. (PLOS Pathogens 2023) infected over 1,000 mice, half of which were vaccinated with BCG, with an ultra low dose (ULD) of Mycobacterium tuberculosis (Mtb); the authors found that BCG...
Tuberculosis (TB) and other mycobacterial infections remain major global health challenges due to their complex, multiscale interactions with the host immune system. Within-host mathematical modelling provides a principled framework for integrating experimental and clinical data and generating mechanistic insight. This Mini symposium will open with a synthesis of within-host mathematical...
