In this round-table discussion, we will examine how much variation can be accepted when the same spatial model is implemented in different software tools, or when similar biological systems are represented using different modelling formalisms. Using examples such as tissue monolayer growth and a basic angiogenesis model, we will discuss where differences arise, how they should be interpreted,...
Multicellular models integrating cell-cell signaling, gene regulation, proliferation and tissue mechanics are needed to unravel the organizational principles of embryo morphogenesis. We(*) here demonstrate, using FAIR and OpenVT principles, how a subcellular element-based blastocyst model can be reproduced in a cellular Potts model (CPM) framework such as Morpheus [1]. The open-source...
Collective cancer invasion often displays a distinct spatial hierarchy, with leader cells at the tips of invasive chains and follower cells trailing behind. Experiments using the Spatiotemporal Genomic and Cellular Analysis (SaGA) platform have shown that these subpopulations differ in motile, signaling, and proliferative behavior. But a fundamental question remains unresolved: what makes a...
Multicellular simulations have become indispensable in understanding complex biological phenomena, from tissue development to disease progression. However, the diversity in simulation methods, ranging from agent-based models to lattice-free models and stochastic particle simulations, poses challenges in terms of reproducibility, modularity, reusability, and integration within multi-scale...
